Figure 2From: Modeling gene-by-environment interaction in comorbid depression with alcohol use disorders via an integrated bioinformatics approach Top scoring GeneGo network including TNF and MTHFR. This four-gene network is the best fit found by GeneGo (p-value 3.45e-08) for TNF and MTHFR. TNF (TNF-alpha) activates TNFR (TNF-R1), which then activates NF-kB. NF-kB regulates the expression of both MTHFR and TNF, creating a feedback loop among TNF, TNFR, and NF-kB.Back to article page