| Identifying Candidate Genes | |
---|---|---|
 | WGA | Text Based Search |
Data Source | Genotyping and Phenotyping | Entrez Gene |
Current Availability of Data | Limited | Available |
Expense | High | Free (Taxpayer Subsidized) |
Sensitivity | Low; limited number of markers tested | Low; much remains unknown about most genes |
Positive Predictive Value | Low; many false positives | High; curated information is backed by experimental data and peer review |
Population Specific | Yes | Generally no, although population specific information may be included in some records |
Specific Variants Identified | Yes, although SNPs that tag haplotypes may not be disease causing variants | Generally no, although specific variants may be annotated. Separate genotyping is usually required for validated candidates |
Multi-Gene Effects on Phenotype | Limited | Yes |
Complex Phenotypes | Limited | Yes |