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Table 5 Ranking of Gene Ontology processes for GeneGo network in Figure 2

From: Modeling gene-by-environment interaction in comorbid depression with alcohol use disorders via an integrated bioinformatics approach

Gene Ontology Process

p-value

positive regulation of transcription from RNA polymerase II promoter

3.8E-06

negative regulation of interleukin-12 biosynthetic process

5.3E-06

inflammatory response

9.5E-06

positive regulation of I-kappaB kinase/NF-kappaB cascade

1.5E-05

positive regulation of transcription, DNA-dependent

1.5E-05

regulation of I-kappaB kinase/NF-kappaB cascade

1.8E-05

positive regulation of transcription

2.9E-05

positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process

3.3E-05

regulation of interleukin-12 biosynthetic process

3.8E-05

interleukin-12 biosynthetic process

3.8E-05

response to wounding

3.9E-05

interleukin-12 production

4.8E-05

  1. Regulation of transcription is the most significantly over-represented Gene Ontology process for this network, consistent with the hypothesis that environmental influences, via ethanol exposure, are transduced through this genetic network to alter TNF and MTHFR expression, folate metabolism, and susceptibility to depression.
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BioData Mining

ISSN: 1756-0381