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Table 1 Comparison of different prediction methods

From: A simple structure-based model for the prediction of HIV-1 co-receptor tropism

Method

Sensitivity

Specificity

geno2pheno

0.31

0.98

wetcat

0.63

0.98

T-CUP

0.68

0.98

T-CUP 2.0

0.70

0.98

Bozek et al.*

0.75*

0.96*

T-CUP

0.73

0.95

Bozek et al.

0.81

0.95

T-CUP 2.0

0.85

0.95

T-CUP

0.81

0.83

Bozek et al.

0.94

0.83

T-CUP 2.0

0.95

0.83

  1. Methods are evaluated on an independent test set of 74 sequences collected from the literature with experimentally validated tropism. *:The method of Bozek et al. does only provide results for a specificity ≤ 0.96.