Table 6 Top regulators for eQTL-hotspot gene groups predicted by the SPF method in wWormNet

Juvenile worms

1

I

K09H9.2,

Endocytosis/

clec-53

regulation of growth rate

R12E2.2

1

I

W01B11.1

1

I

sep-1

Cell division

1

I

mis-12

Cell division

1

I

Y54E10BR.3

TF/Zn ion binding

1

I

Y71F9B.6

2

V

fbxa-192

Protein interaction

2

V

str-92

2

V

T10C6.7

Protein interaction

2

V

Y59A8A.3

Reproducing worms

3

IV

Y55F3BL.2

Metal ion transport

3

IV

Y69A2AR.16

Metabolism/oxidoredutase

3

IV

Y69A2AR.21

Embrionic development

4

V

Y32B12A.5

4

V

Y43F8B.13

4

V

Y43F8B.14

4

V

Y51A2B.4

Lipid metabolism

4

V

Y70C5B.1

4

V

srh-296

Integral membrane component

Old worms

5

II

moe-3

RNA binding/iRNA modification

5

II

Y17G7B.18

Positive regulation of growth rate/development

5

II

cpt-1

Acetyl-transferase/histone modification

5

II

csp-1

Caspase/apoptosis

5

II

pqn-87

Prion/protein modification

6

IV

F15E6.4

6

IV

F28F9.3

6

IV

T08B6.4

6

IV

Y9C9A.1

Structural element of vitelline membrane

7

IV

C17H12.12

Protein binding

7

IV

C17H12.5

Tyrosine phosphatase

7

IV

C31H1.1

7

IV

F36H12.5

7

IV

F38A5.6

7

IV

ZK354.3

8

V

Y38H6C.15

8

V

Y38H6C.18

8

V

tgt-2

Queuine tRNA-ribosyltransferase activity modification

8

V

T26E4.10

Lipid storage

8

V

T26F2.2

8

V

sri-7

Integral membrane component

8

V

nhr-218

TF,steroid hormon receptor

8

V

str-151

Integral membrane component

8

V

nhr-269

TF,steroid hormon receptor