Table 2 The major targets of ginger for colon cancer treatment and the topological parameters

P42336

PIK3CA

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

42

0.187322

0.572254

P12931

SRC

Proto-oncogene tyrosine-protein kinase

38

0.107991

0.568966

P27986

PIK3R1

Phosphatidylinositol 3-kinase regulatory subunit alpha

38

0.106891

0.568966

P04637

TP53

Cellular tumor antigen p53

35

0.103695

0.546961

P27361

MAPK3

Mitogen-activated protein kinase 3

33

0.084312

0.543956

P40763

STAT3

Signal transducer and activator of transcription 3

31

0.080670

0.535135

P31749

AKT1

RAC-alpha serine/threonine-protein kinase

29

0.068649

0.532258

P07900

HSP90AA1

Heat shock protein HSP 90-alpha

27

0.066522

0.529412

P45983

MAPK8

Mitogen-activated protein kinase 8

23

0.065784

0.502538

O60674

JAK2

Tyrosine-protein kinase JAK2

20

0.056021

0.497487

P42338

PIK3CB

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform

19

0.036367

0.492537

P00533

EGFR

Epidermal growth factor receptor

19

0.028652

0.485294

Q05513

PRKCZ

Protein kinase C zeta type

18

0.021649

0.480583

Q05655

PRKCD

Protein kinase C delta type

18

0.021286

0.478261

P23458

JAK1

Tyrosine-protein kinase JAK1

18

0.017349

0.478261

P03372

ESR1

Estrogen receptor

18

0.016778

0.473684

Q04206

RELA

Transcription factor p65

17

0.014046

0.469194

Q16539

MAPK14

Mitogen-activated protein kinase 14

17

0.011251

0.469194

Q05397

PTK2

Focal adhesion kinase 1

15

0.009972

0.464789

Q02750

MAP 2 K1

Dual specificity mitogen-activated protein kinase kinase 1

15

0.009205

0.464789

P04626

ERBB2

Receptor tyrosine-protein kinase erbB-2

15

0.008965

0.464789

P42574

CASP3

Caspase-3

15

0.008693

0.462617

P04150

NR3C1

Glucocorticoid receptor

14

0.00863

0.460465

P05412

JUN

Transcription factor AP-1

14

0.008501

0.458333

P52333

JAK3

Tyrosine-protein kinase JAK3

14

0.008096

0.450000

P06493

CDK1

Cyclin-dependent kinase 1

14

0.007042

0.450000

P17252

PRKCA

Protein kinase C alpha type

13

0.006885

0.447964

P10275

AR

Androgen receptor

13

0.005944

0.445946

P08069

IGF1R

Insulin-like growth factor I receptor

11

0.005841

0.443946

O14965

AURKA

Aurora kinase A

11

0.005668

0.440000

P00519

ABL1

Tyrosine-protein kinase ABL1

11

0.005616

0.432314

Q00987

MDM2

E3 ubiquitin-protein ligase Mdm2

10

0.00552

0.415966

P24941

CDK2

Cyclin-dependent kinase 2

10

0.004538

0.415966

P49841

GSK3B

Glycogen synthase kinase-3 beta

8

0.004458

0.415966